![]() ![]() This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Supported by a National Institutes of Health grant K23-NS048152, National Institute of Neurological Disorders and Stroke grant UL1 RR024148, National Center for Research Resources and University of Texas Health Science Center at Houston Center for Clinical and Translational Sciences, a Clinical Investigator Award from the Center for Clinical Research and Evidence-Based Medicine at the University of Texas Houston Medical School (NAP), and the Eunice Shriver National Institute of Child Health & Human Development Neonatal Research Network grant U10 HD021373 (KAK). Received: JanuAccepted: MaPublished: May 9, 2013Ĭopyright: © 2013 Parikh et al. ![]() PLoS ONE 8(5):Įditor: Jean-Claude Baron, University of Cambridge, United Kingdom Brain growth measurements in extremely low birth weight infants can advance our understanding of perinatal brain injury and development.Ĭitation: Parikh NA, Lasky RE, Kennedy KA, McDavid G, Tyson JE (2013) Perinatal Factors and Regional Brain Volume Abnormalities at Term in a Cohort of Extremely Low Birth Weight Infants. Regional brain volumes are sensitive to multiple perinatal factors and neonatal morbidities or interventions. Surgery for retinopathy of prematurity and surgery for necrotizing enterocolitis or spontaneous intestinal perforation were significantly associated with increasing volume of white matter hyperintensities. Significant adverse clinical associations for total brain tissue volume included: small for gestational age, seizures, caffeine therapy/apnea of prematurity, duration of parenteral nutrition, pulmonary hemorrhage, and white matter injury ( p<0.01 for each relative difference range: −1.4% to −15.0%). Regional brain volumes were markedly reduced in extremely low birth weight infants as compared to term newborns (relative difference range: −11.0%, −35.9%). Using multivariable linear regression, clinical antecedents were correlated with volumes of total brain tissue, white matter hyperintensities, and regional tissues/structures, adjusted for age at MRI, total cranial volume, and total tissue volume. Brain volumes were measured using semi-automated and manual segmentation methods. A consecutive cohort of extremely low birth weight infants who survived to 38 weeks postmenstrual age (n = 122) and a control group of 16 healthy term newborns underwent brain MRI at term-equivalent age. Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors. ![]()
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